Strengthens teeth and reverses white spot lesions better than the leading brand
Clinpro™ Tooth Crème 0.21% w/w Sodium Fluoride Anti-Cavity Paste is an advanced formula containing an innovative tri-calcium phosphate ingredient and is available exclusively from 3M ESPE. This winning formula is a one-step process requiring patients to simply brush with it once daily, eliminating the two-step regimen currently associated with GC Tooth Mousso Plus*. Clinpro Tooth Crème also delivers more fluoride, helps strengthen enamel and helps reverse white spot lesions better than GC Tooth Mousse Plus.
 A better option
The optimised formula makes Clinpro Tooth Crème an outstanding choice. It contains fluoride
as well as calcium and phosphate, which are components naturally found in saliva. This
proprietary formula successfully integrates these components, enhancing, rather than
compromising, the product’s performance. During the manufacturing process, a protective
barrier is created around the calcium allowing it to coexist with the fluoride ions. As Clinpro Tooth Crème comes in contact with saliva during brushing, and makes
the calcium, phosphate and fluoride readily available to the tooth. The tooth naturally absorbs
these components, helping to prevent the initiation and further demineralisation
and allowing remineralization to occur.
The development of this exceptional 950 ppm fluoride and tri-calcium phosphate formula
is the result of a relationship between 3M ESPE and Indiana Nanotech scientists. 3M ESPE
enlisted world-renowned and expert caries researchers to become part of the development
team. Key players included Dr. George Stookey, a pioneer in caries research and key
contributor to developing the world’s first clinically proven fluoride toothpaste, Dr. Robert
Karlinsey, an emerging leader in developing dental and biomedical technology applications,
and the 3M ESPE Preventive Research Team led by Aaron Pfarrer.
What is fTCP and what benefits does it
offer?
fTCP is a name given to the innovative
calcium-based additive we use in our
preventive products. One of the major
components of the additive is tri calcium
phosphate. What makes it so innovative is
the way in which we prepare tri-calcium
phosphate so that it can co-exist with
fluoride in an aqueous environment. In
very simple terms, tri-calcium phosphate
is specially milled with a simple organic
ingredient known as “Sodium Lauryl
Sulfate” (SLS) found in nearly all
toothpaste formulations. During the
milling process, we functionalise the
TCP resulting in an organic-calcium
phosphate hybrid being formed. This
importantly ensures that the Calcium
oxides are protected from the undesirable
interactions with fluoride, which could
render both calcium and fluoride inactive.
How is the Calcium and Flouride
absorbed by the tooth?
The combination of fluoride uptake and
remineralisation tells us. (A) Fluoride
uptake tells us that fluoride was indeed
delivered to the lesion (pH cycling is the
best way to tell if it was substantive rather
than just loosely bound/labile fluoride).
(B) Remineralisation tells us that mineral
deposition/remineralisation occurred.
Again, pH cycling (exposing the tooth
structure to periods of remin and demin
episodes) tells us if the mineral was
substantive. So, fluoride uptake basically
tells us how much mineral was absorbed
and remineralisation tells us about the
quality of the mineral formed.
It has been well proven and documented
many times that calcium alone will
not prevent caries but Calcium &
Fluoride will. Fluoride when applied to
demineralised enamel or dentin helps
form fluoroapatite. This mineral formed
in the presence of fluoride is much more
resistant to an acid challenge than mineral
formed in its absence.
Can Clinpro Tooth Crème help in
achieving remineralisation at both
surface and sub-surface?
Yes. We have subsequently conducted
additional experiments ( DI Water
Vs Normal OTC NaF toothpaste Vs
Clinpro Tooth Crème) and observed
locations in the body of the lesion
where remineralisation occurred - What
really matters is that the lesion (the
subsurface) was demineralised. At all
points (surface to base of the lesion) better
remineralisation was observed when fTCP
was added.
"Strengthens teeth and reverses white spot lesions better than the leading brand"
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